Hatcher, a SAG and Golden Globe-winning actress, most recently appeared opposite Matthew Perry and Thomas Lennon in a recurring role on NBC’s comedy series The Odd Couple. Besides Lois & Clark and a lengthy run as the lad on ABC's Desperate Housewives, Hatcher has appeared in films like Soapdish, The Big Picture, and Tomorrow Never Dies. She was also a student at Le Cordon Bleu and a New York Times-bestselling author. She also has more than two decades of charity work behind her, even speaking at the U.N. as part of Ending Violence Against Women.

"No offense to any of the wonderful actresses who have also played the part, but Teri Hatcher is my all time favorite Lois Lane," said Supergirl executive producer Andrew Kresiberg. "To have her come back to the SuperWorld in a completely different part is an unbelievable gift to me, Greg [Berlanti], and the fans.”

The Lois & Clark alum has booked a multi-episode arc on Supergirl, EW has learned. Hatcher will be playing a mysterious new role that will become the new Big Bad of Season 2.

Fun fact: The first big bad of the season, Lillian Luthor, was played by Hatcher’s former Desperate Housewives co-star Brenda Strong. Lillian has since been arrested, but an upcoming storyline will find her going on the lam. Could Hatcher’s mysterious character be the new leader of Project Cadmus? And if so, will that reunite her with Dean Cain, who portrays the M.I.A. Danvers patriarch?

Hatcher is no stranger to the world of Superman. Following her turn as Lois Lane for The New Adventures of Superman, the actress had a brief role on Smallville. She most recently appeared on CBS comedy The Odd Couple. “No offense to any of the wonderful actresses who have also played the part, but Teri Hatcher is my all time favorite Lois Lane,” says executive producer Andrew Kreisberg. “To have her come back to the SuperWorld in a completely different part is an unbelievable gift to me, Greg [Berlanti], and the fans.”

The actress — who joins other familiar faces on Supergirl from the world of superheroes, like Cain, Helen Slater, and Lynda Carter is set to join the series this winter.